S21-374 Targeted locoregional delivery of therapeutic extracellular vesicles with enhanced bioenergetic profile Researchers at Stanford have developed a novel cell-free stem cell derived extracellular vesicle (EV) therapy powered by pulsed focused ultrasound (pFUS) that enhances its therapeutic and bioenergetic effect. Avnesh Thakor Shashank Chetty Shobha Regmi Abantika Ganguly