S21-353 Small interfering RNA (siRNA) therapy PLN-R14del cardiomyopathy Phospholamban (PLN) regulates cardiac contractility and modulates sarcoplasmic reticulum (SR) Ca2+ sequestration by inhibiting the dephosphorylated SR Ca2+-ATPase (SERCA). Ioannis Karakikes Pieter Glijnis
S18-305 Therapeutic targeting of the Platelet-Derived Growth Factor (PDGF) signaling pathway in dilated cardiomyopathy Dilated cardiomyopathy (DCM) is principally characterized by left ventricular enlargement and/or a reduction in systolic function. Vittavat Termglinchan Ioannis Karakikes Joseph Wu Jaecheol Lee Sebastian Diecke