Inventors at Stanford developed a method to leverage mass cytometry, a type of flow cytometry utilizing mass spectrometry, for the detection of heavy metals in leukocytes from individuals exposed to heavy metals in elevated air pollution.
Researchers in Dr. Holden Maecker's lab have developed platinum-labeled probes to expand the analytical capacity of mass cytometry instruments. Currently, analytical capacity is limited by the ability to label specific probes with appropriate metal ions.
Engineers in Prof. Amin Arababian's laboratory have developed a microfluidics system for ultra high-throughput, low-cost, label-free cell detection in liquid biopsies, fetal cell analysis and other applications.
Stanford researchers have developed a statistical algorithm termed Single Cell Linkage Using Distance Elimination (SLIDE) to analyze large-scale data sets without reducing their dimensionality, including those generated by single-cell mass cytometry.
GateFinder is a flexible, automated, objective algorithm that quickly analyzes complex mass cytometry datasets to identify simple signatures (“gates”) for FACS (fluorescent automated cell sorting) purification.