Stanford researchers have developed a new gene editing approach that enables red blood cell-specific gene expression for the treatment of enzyme deficiencies.
The coronavirus main protease (Mpro), which is a trypsin-like protease with a catalytic cysteine residue, processes viral proteins in an early step of the coronavirus life cycle, and its activity is required for viral replication.
Researchers at Stanford have combined 3D printing and pyrolysis to produce a robust and biocompatible high resolution micro-array patch (MAP) for transdermal drug delivery.
Researchers at Stanford have developed engineered IL-2 "surrogate" mutant agonists with varying patterns of STAT1/3/5, ERK, and PI3K signaling, as well as preferential induction of memory T cell differentiation and NK cell cytotoxicity relative to native IL-2.
Scientists in Sergiu Pasca's group at Stanford University have used patient-derived organoids, assembloids and in vivo transplantation to discover and validate an antisense oligonucleotide drug for the treatment of Timothy syndrome.
Stanford researchers have engineered chimeric cytokine receptors that are expressed in therapeutic cells to enhance their activity and therapeutic potential.
There is broad potential to modulate RNA using small molecules, replacing more costly and difficult-to-administer oligonucleotide therapies. However, methods for screening for such small molecules are lacking.
Stanford researchers have developed a scalable assay that combines single-molecule nucleic acid imaging with single-cell sequencing, enabling the enrichment and detailed study of rare cell populations in complex biological samples.
Stem cells are generally influenced by a microenvironmental niche, typically comprised of epithelial and mesenchymal cells and extracellular substrates. Many attempts have been made to produce culture systems that mimic normal intestinal epithelial growth and differentiation.
Patients with celiac disease have a pathological reaction to gluten and have either HLA-DQ2+ (90%) or HLA-DQ8+, but expression of these MHC class II haplotypes is not sufficient and other factors are necessary for the development of celiac sprue.
Researchers at Stanford have found that a vaccine, enhanced with adjuvants that imprint an antiviral state on innate immune cells and non-hematopoietic organ cells, could confer lasting nonspecific protection against diverse pathogens.
Researchers in Stanford University's EXtreme Environment Microsystems Laboratory (XLab) working in collaboration with the University of Arkansas' Mixed-Signal Computer-Aided Design (MSCAD) Laboratory developed a Hall-effect sensor design that detects ultra fast changes in the
Different drug delivery agents, including synthetic polymers, virus-based vectors, lipid-based vectors, and extracellular vesicles (EVs), have been explored previously.
Stanford scientists have developed a working model that chemotherapy drugs induce peripheral neuropathy by activating a pathway that favors neuronal degeneration and impairs sensory neuron function.