Researchers at Stanford have discovered new, chemically distinct opioid receptor ligands that may be used to develop safer opioid therapeutics. Opioids are ligands that bind to the mu, delta, and/or kappa opioid receptors.
Stanford researchers have patented a hydrogel system which allows for the easy encapsulation of cells and biomolecules without requiring external changes in environmental conditions or exposure to chemical crosslinkers.
Engineers in Prof. Zhenan Bao's lab have developed highly conductive, stretchable composite hydrogel materials that can be used as soft electrodes that match the mechanical properties of a range of biological tissues.
Researchers at Stanford and their colleagues have developed easily expressed Wnt agonist and antagonists. Wnts are central mediators of development as they influence cell proliferation, differentiation and migration.
Researchers in Prof. Brian Feldman's laboratory have developed a patented drug screen to identify compounds that could potentially treat obesity and metabolic disease by converting cells to calorie-burning brown fat.
Summary: Stanford researchers at the Melosh Lab have proposed a non-invasive, high electrode density, high resolution (100 micrometers to 10 nanometers) neural device implantation for electrical stimulation of neural/biological tissues.
Researchers at Stanford have developed methods to identify and treat MYC-driven cancers, including renal cell carcinoma (RCC). RCC is a common, aggressive type of kidney cancer and effective therapeutics are lacking.
Stanford researchers have developed an injectable, biocompatible hydrogel consisting of extracellular matrix (ECM) from human cadaveric tendons as a potential scaffold for guided tissue regeneration and tissue engineering purposes.
Researchers in Prof. Irving Weissman's laboratory have developed cell culture techniques to rapidly and efficiently derive pure populations of mesodermal cells from human pluripotent stem cells (hPSCs).
Researchers at Stanford have engineered proteins to selectively sensitize T cells to IL-2. The ability to manipulate immune cells for therapeutic use is of great clinical interest. Cytokines are signaling molecules that can be used to alter cellular behavior.
Researchers in Prof. Karen Parker's laboratory have discovered a biomarker that could enable an objective laboratory-based test for diagnosing autism spectrum disorders (ASD) and predicting the severity of a patient's symptoms.
Researchers at Stanford have developed methods using click chemistry to immobilize and concentrate therapeutic factors on a tissue to improve wound healing.
Researchers at Stanford have developed methods to promote bone healing in people with diabetes. Diabetes is a chronic metabolic disease associated with many clinical complications including impaired bone healing.
Researchers at Stanford have developed methods to classify and treat MYC-driven hematopoietic cancers. The MYC oncogene drives the proliferation and survival of many hematopoietic cancers. These cancers are highly aggressive and do not respond to conventional chemotherapies.