Researchers at Stanford have facilitated active agent passage across the blood-brain barrier (BBB) by conjugating the active agent with a plasma protein that gets taken up by microglia.
Stanford scientists pioneer the use of Fibroblast growth factor 17 (Fgf17) to restore memory and treat associated age-related diseases and conditions by rejuvenating oligodendrocytes which are crucial for myelin repair in aging and other neurodegenerative diseases.
Stanford researchers have patented methods to improve phagocytosis, the process by which macrophages clear protein aggregates, dying cells, and debris, to treat age-related diseases.
Researchers in the Wyss-Coray Lab are investigating a potential therapeutic antibody to treat lysosomal storage disorders and other related neurodegenerative diseases.
Stanford researchers have identified lipid droplet accumulating microglia (LAM) in aging brains, proposing that these microglia play a role in neurodegenerative disease.
Stanford researchers have developed a molecular diagnostic for Alzheimer's disease (AD) based on their recent discovery of an immunologic signature. While innate inflammation has been implicated in AD, little is known about the role of the adaptive immune response.
Researchers in Dr. Anton Wyss-Coray's lab have identified a new therapeutic avenue for treatment of age-related neurodegenerative diseases. Cerebrovascular changes and inflammation are key features of brain aging and neurodegeneration.