Dr. Greg Barsh and Dr. Allison Xu have generated transgenic mice that express Cre recombinase under control of regulatory elements from agouti-related protein (Agrp). The Agrp neurons are critical for regulation of a wide variety of metabolic functions.
Stanford researchers have developed a system for precise genetic modification of human embryonic stem cells (ECSs) and induced pluripotent stem cells (iPSCs).
To better understand how the brain processes information and generates behavior, researchers in Dr. Liqun Luo's lab have generated the FosTRAP and ArcTRAP mouse strains.
Dr. Andrea Meredith and Dr. Richard Aldrich have generated a viable mouse knockout KCNMA1, the gene encodes the pore-forming subunit of the BK large conductance calcium-activated potassium channel (also called KCa1.1, SLO1, and MaxiK).
Researchers in Prof. Karl Deisseroth's laboratory have developed specific, inducible animal models for depression that use targeted optogenetic strategies to precisely dissect the neuronal circuits underlying the condition.
Researchers in Prof. Robert Malenka's laboratory have developed a light-activated animal system that could be used to identify compounds that treat certain psychiatric disorders.
Researchers in Dr. Laura Attardi's lab have created a knock-in mouse strain which generates a form of p53 that is not subject to degradation by the proteasome.
Researchers in Dr. Roeland Nusse's laboratory have generated an Axin2CreERT2 knock-in mouse strain that can be used to identify and map stem cells in any tissue. The Wnt/β-catenin signaling pathway is instrumental for stem cell maintenance in multiple tissues.
Hemizygous mice are viable and fertile with no anatomic abnormalities. Transgene expression is observed in aorta, heart, and brain. Transgenicdimethylarginine dimethylaminohydrolase (DDAH) activity is reflected in a reduction of plasma asymmetric dimethylarginine (ADMA).
Researchers in Prof. Liqun Luo's laboratory have developed a mouse model system for in vivo, non-invasive, spatially- and temporally-controlled labeling of individual synapses.
The minicircle is a non-viral DNA vector for non-insertional transgene expression. A typical minicircle contains a transgene expression cassette, and is free of all other plasmid DNA elements, including an antibiotic resistance gene and a plasmid DNA replication origin.
Stanford researchers have developed a highly specific, tunable system to improve the safety, efficacy and deliverability of gene therapy vectors and other biological therapies.