Dr. Rosemarie DeKruyff and colleagues have generated an agonistic TIM-1 monoclonal antibody (mAb), called TIM-1 mAb 3B3. TIM-1 plays critical roles in regulating immune cell activity and is also involved in allergic response and asthma.
Researchers in Dr. Dean Felsher's lab have generated a murine hepatocellular carcinoma (HCC) cell line with controllable MYC expression. HCC is one of the most common and incurable malignancies.
Stanford researchers developed BAP1, a strain of E. coli designed to produce complex natural products (particularly polyketides and non-ribosomal peptides) that might otherwise be inaccessible.
Researchers in Prof. Hanlee Ji's laboratory have developed an automated method to capture and directly sequence target DNA with next-generation sequencing.
Dr. Richard Zare and colleagues have developed an inexpensive, fast and simple method for treating polyethylene terephthalate (PET) blood collection tubes (BCTs) to remove bias and interference in various blood analysis procedures.
Researchers in Dr. Shoshana Levy's lab have created a pro B cell lines that provides the first B cell lineage tumors in a C57BL mouse strain. The cell lines, known as H11 and 2F3, were made by transducing mouse bone marrow with BCR-ABL retrovirus.
This invention provides a stem cell culture medium with small molecule inhibitors that can be used to maintain pluripotency in a laboratory atmospheric environment.
Researchers in Dr. Michael Lin's lab have developed a fluorescent voltage sensor for non-invasive optical monitoring of electrical events in living cells in vitro and in vivo.
Researchers in Dr. Roeland Nusse's lab have developed a mouse monoclonal antibody to ROR2 (Nt 2535-2835). ROR2 is a membrane bound receptor tyrosine kinase that is activated by non-canonical Wnt signaling through its association with Wnt5.
Stanford and Rockefeller researchers have identified and developed dynein-specific inhibitors that have significant medical applications involving mitotic spindle assembly, organelle transport, and primary cilia formation.
Researchers in Dr. Or Gozani's laboratory have produced lysine methyltransferases, histone octomers, purified nucleosomes, and antibodies for use in chromatin and epigenetic research.
Researchers in the laboratories of Dr. Eric Kool and Dr. Howard Chang have created and characterized chemical probes that enable accurate RNA structural analysis in living cells. RNA structure plays an important role in practically every facet of gene regulation.