Neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have been characterized by the expansion of the GGGGCC hexanucleotide repeat within the non-coding region of the human chromosome 9 open reading frame 72 (C9ORF72) gene.
Stanford researchers in the laboratory of Dr. Daria Mochly-Rosen have developed novel small molecules for modulating ALDH2 (mitochondrial aldehyde dehydrogenase-2).
Researchers at Stanford have developed prodrug derivatives of protein kinase C (PKC) modulators that have lower toxicity and are more effective than the parent compound. PKC modulators are being developed to treat a variety of diseases.
Stanford researchers developed a first-in-class small-molecule inhibitor of the CLC-2 ion channel for research and drug development. CLC-2 is part of the CLC family of chloride ion channels, which regulate the flux of chloride ions across cell membranes.
Stanford researchers have identified lipid droplet accumulating microglia (LAM) in aging brains, proposing that these microglia play a role in neurodegenerative disease.
A team of Stanford scientists have developed a technique to rapidly convert adult somatic cells directly into functional neuronal cells without the intermediate step of generating iPS cells (induced pluripotent stem cells).
Stanford researchers have designed a frequency-multiplexed neural probe architecture that enables massive scaling of electrophysiological recording from neurons.
Stanford researchers have designed a non-invasive, low power ultrasonic neuromodulation device which can target tissue deep in the brain with high spatial-temporal resolution.
Researchers at Stanford have developed a combination therapy to treat neuroblastoma, the most common and deadly solid tumor in childhood. Neuroblastoma derives from neural crest cells that fail to exit the cell cycle and differentiate.
Engineers at the Khuri-Yakub Group have designed a non-surgical alternative for treating epilepsy using ultrasonic technology which can detect, localize, and suppress epileptic seizures in epileptic patients.
Researchers at Stanford are developing methods of using arginine vasopressin (AVP) to improve social abilities of children with autism spectrum disorder (ASD). Autism is a neurodevelopmental disorder characterized by social impairments (e.g.
Summary: Stanford researchers at the Melosh Lab have proposed a non-invasive, high electrode density, high resolution (100 micrometers to 10 nanometers) neural device implantation for electrical stimulation of neural/biological tissues.
Researchers in Dr. Anton Wyss-Coray's lab have identified a new therapeutic avenue for treatment of age-related neurodegenerative diseases. Cerebrovascular changes and inflammation are key features of brain aging and neurodegeneration.
Researchers in Dr. Michelle Monje-Deisseroth's lab at Stanford have recently identified therapeutic targets for drug development to limit the spread of high-grade gliomas (HGGs).