Pluripotent stem cells (PSCs) arise during early embryogenesis and can give rise to entire animals. Yet, comprehension of pluripotency regulation remains incomplete, highly species-specific, and primarily limited to mouse and human.
Hematopoietic stem and progenitor cells, collectively "HSPCs", are multipotent cells that can self-renew and differentiate into all types of blood cells, including cells of both myeloid and lymphoid lineage.
Researchers at Stanford University have discovered that donor-specific anti-HLA antibodies can be used to detect and treat graft-versus-host disease (GVHD) in transplant recipients after allogenic transplantation.
Stanford researchers have developed an LVCTM3 system for producing lentiviral vectors and other viral particles, offering a cost-effective, simplified and scalable solution for various applications from gene therapy to vaccine development.
Stanford researchers have discovered using a novel assay that a large proportion of CRISPR/AAV modified cells contain hidden concatemeric knockins that affect gene expression, and therefore developed a strategy to reduce their occurrence.
Researchers at Stanford University have developed a novel platform for genetically engineering cells within a living organism, circumventing previous limitations related to accessing target tissues and the size of the genetic payload.
Cell culture is a central technique used for a plethora of research applications including in the modeling of complex diseases, creating transgenic animals, gene therapy, cell therapy, regenerating lost tissue, and organ biogenesis.
Researchers in the Nakauchi lab at Stanford University have shown that the contribution of human donor cells to tissues and organs can be increased in an interspecies host embryo by knocking out insulin growth factor 1 receptor (Igf1r).
Researchers at Stanford have developed chemically defined, polyvinyl alcohol (PVA)-based media for culturing hematopoietic stem cells and immune cells (e.g., T cells).