Researchers at Stanford have developed a method to tag and identify disease associated proteins for the development of prognostic or diagnostic biomarkers. Biomarker discovery is foundational to the effective treatment and management of numerous diseases.
Stanford researchers have developed a novel, cell-free platform for rapid and high-throughput protein function analysis. This technology harnesses hydrogel bead-based emulsification to parallelize and screen DNA-encoded protein libraries in a scalable, efficient manner.
Saccharomyces cerevisiae strain BCY123 is provided as an ampoule containing viable cells (yeast cells, spores, or agar cubes with mycelia) suspended in cryoprotectant. This strain can be used for protein production in yeast.
Stanford researchers have developed a novel CRISPR-based method, Oligo-LiveFISH, for generating large-scale pools of synthetic RNA oligos that enable multiplexed targeting, imaging, and manipulation of genomic regions in living cells.
Stanford scientists have developed cross-reactive antibodies that can bind human and murine NKp46 on NK cells and induce cytotoxicity and proliferation.
Stanford researchers have developed a high-affinity IL-11 decoy cytokine for super-agonism and antagonism of the IL-11 receptor, enabling the treatment of a wide variety of diseases from inflammatory disease to cancer as well as research into IL-11 signaling pathways.
Researchers at Stanford have developed a rapid and efficient method for high-throughput genome editing using CRISPR/Cas9. The CRISPR/Cas9 system allows researchers to edit any site in an organism's genome.
Researchers at Stanford have developed a method using expressed genetic barcodes to enable simultaneous lineage tracing and single cell profiling. Intratumor heterogeneity fosters tumor evolution which is a key contributor to therapeutic failure and the lethality of cancer.
Researchers in the Appel lab have developed hydrogels for tumor inoculation that improve precision and statistical power in preclinical mouse models of cancer.
Tracking in vivo cell distribution, migration, and engraftment using conventional techniques including MRI, PET/CT and conventional optical imaging is often hindered by low resolution, radioactive risks, and limited tissue penetration depth.
Researchers at Stanford have developed chemically defined, polyvinyl alcohol (PVA)-based media for culturing hematopoietic stem cells and immune cells (e.g., T cells).
Researchers in Dr. Karl Deisseroth's lab have developed a selective approach to treat anxiety. Anxiety is characterized by several features that are coordinately regulated by diverse neuronal system outputs.