Stanford researchers developed and patented a multiplexed immunohistochemistry method called multiplexed ion beam imaging (MIBI), which uses antibodies tagged with non-biological elemental isotopes (e.g. rare earth elements) and secondary ion mass spectroscopy.
Inventors at Stanford developed a method to leverage mass cytometry, a type of flow cytometry utilizing mass spectrometry, for the detection of heavy metals in leukocytes from individuals exposed to heavy metals in elevated air pollution.
Researchers in Dr. Holden Maecker's lab have developed platinum-labeled probes to expand the analytical capacity of mass cytometry instruments. Currently, analytical capacity is limited by the ability to label specific probes with appropriate metal ions.
Researchers in Prof. Sylvia Plevritis' laboratory have developed an algorithm designed to optimize cancer combination therapy for individual patients by analyzing distinct single-cell responses from heterogeneous tumors.
GateFinder is a flexible, automated, objective algorithm that quickly analyzes complex mass cytometry datasets to identify simple signatures (“gates”) for FACS (fluorescent automated cell sorting) purification.