Lab designation: RA3 6B2; A rat-mouse hybridoma cell line producing a monoclonal IgG2a rat AB which recognizes a B cell specific form of the T200 family of cell surface glycoproteins. B220 was first characterized by another MAB, RA3-3A1.
This antibody is directed against the human LMO2 antigen, which is expressed as a transcription factor in certain lymphomas and leukemias. We have recently shown that it identifies those lymphomas derived from germinal center B cells.
Osteopontin is a protein involved in the pathogenesis of cancer and chronic inflammatory diseases. Antibodies are a powerful tool that can be used to target this protein and regulate its pathway.
Researchers at Stanford University and the CZ Biohub San Francisco have developed a strategy for retrieving and cloning antibody DNA from single cells within a pooled library of cells, enabling the rapid and low-cost cloning and expression of native human antibodies for functi
LS722 is a rat IgG monoclonal antibody shown to recongnize mouse b7. The antibody has been found to enhance a4b7-mediated lymphoid cell binding to a4 integrin substrates.
Rat monoclonal antibody BZ332 specifically recognizes human serpentine protein CMKLR1. CMKLR1 is a novel protein possessing high homology with members of the chemoattractant receptor family, and binds the chmoattractant chemerin.
Researchers at Stanford have identified amino acid modifications in the IgG Fc region which extend its therapeutic half-life and improve its in vivo receptor binding.
Researchers in the Felsher Lab at Stanford University have developed PD-L1 antibody fragment-conjugated nanoparticles to improve upon existing cancer immunotherapies and extend the range of indications to solid tumors.
Dr. Brian Zabel and Prof. Eugene Butcher have developed rat monoclonal antibodies (clones BZ2E3 and BZ5B8, rIgG2aκ isotype) to the mouse chemokine (CC motif) receptor-like 2 (CCRL2) protein.
Researchers at Stanford University and Johns Hopkins University have identified an antibody that is negatively associated with cancer in patients diagnosed with dermatomyositis.
Researchers in Dr. Roeland Nusse's lab have developed a mouse monoclonal antibody to ROR2 (Nt 2535-2835). ROR2 is a membrane bound receptor tyrosine kinase that is activated by non-canonical Wnt signaling through its association with Wnt5.
Stanford researchers in Dr. Taia Wang's lab have developed a technology that utilizes swainsonine to enhance the cytotoxic potency of monoclonal antibodies, thereby improving their efficacy in cancer and autoimmune disease treatments.
The 4G7 hybridoma secretes an IgG1 antibody that is specific for normal and malignant B lymphocytes and can be used for the study of B cell differentiation and for the characterization of lymphoid malignancies.