Researchers in the Felsher Lab at Stanford University have developed PD-L1 antibody fragment-conjugated nanoparticles to improve upon existing cancer immunotherapies and extend the range of indications to solid tumors.
Dr. Brian Zabel and Prof. Eugene Butcher have developed rat monoclonal antibodies (clones BZ2E3 and BZ5B8, rIgG2aκ isotype) to the mouse chemokine (CC motif) receptor-like 2 (CCRL2) protein.
Researchers at Stanford University and Johns Hopkins University have identified an antibody that is negatively associated with cancer in patients diagnosed with dermatomyositis.
Researchers in Dr. Roeland Nusse's lab have developed a mouse monoclonal antibody to ROR2 (Nt 2535-2835). ROR2 is a membrane bound receptor tyrosine kinase that is activated by non-canonical Wnt signaling through its association with Wnt5.
Stanford researchers in Dr. Taia Wang's lab have developed a technology that utilizes swainsonine to enhance the cytotoxic potency of monoclonal antibodies, thereby improving their efficacy in cancer and autoimmune disease treatments.
The 4G7 hybridoma secretes an IgG1 antibody that is specific for normal and malignant B lymphocytes and can be used for the study of B cell differentiation and for the characterization of lymphoid malignancies.
The limited duration of humoral responses to vaccination is a key issue in the fight against infectious diseases, as antibody levels wane over time, leaving individuals vulnerable to reinfection.
Stanford scientists have discovered that bispecific antibodies can selectively bind cancer cells and block the CD47-SIRPα "don't eat me signal" to efficiently clear tumors with negligible toxicity.
Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed PMD (Protect, Modify, Deprotect), an immunofocusing strategy that can be used in vaccine development for the generation of antibodies targeting a specific epitope.
Stanford researchers have developed a PCR-based method that detects disease-relevant, isotype-specific antibodies and can be used to diagnose allergy. Allergy is a prevalent immune hypersensitivity disease that affects more than 20% of the US population.
Researchers in Prof. Irving Weissman's lab have developed and patented antibodies and methods to prevent the formation of teratomas from human pluripotent stem cells used for regenerative medicine, cell therapy or research.