Researchers at Stanford have developed FiberFold, a computational tool enabling the rapid analysis of 3D chromatin architecture in conjunction with chromatin accessibility, CTCF binding, CpG methylation, and underlying genetic architecture.
Stanford researchers have developed the Broadly Usable Multi-Pass Engineered Receptor (BUMPER) architecture, a novel protein engineering platform for assembling stable, multifunctional cell surface receptors.
Stanford scientists have developed the Programmable Antigen-Mediated Cellular Knock-in of T cell (PACK-IT) platform that enables rapid CAR-T cell engineering in hours rather than weeks.
Stanford scientists have developed a method to selectively expand CAR-T cells by co-delivering IL9R with CAR genes using a novel platform that enables rapid CAR-T cell engineering through targeted lentiviral delivery.
Stanford researchers have developed EphrinA3 technology to strengthen epithelial barriers by increasing expression of cell-cell adhesion molecules, particularly desmoglein-1 (DSG1) and desmocollin-1 (DSC1).
Stanford researchers have developed a general system to regulate the activities of specific proteins in mammalian cells using cell-permeable, synthetic molecules.
Stanford scientists have developed Plate-C, a high-throughput screening platform that captures genome-wide 3D chromatin architecture as a comprehensive cellular phenotype.
Stanford researchers have developed a novel technology called FLASH (Functional Assigning Sequence Homing) that predicts phenotypes directly from raw sequencing data, bypassing assembly and alignment, while revealing the biological features driving those predictions.
Researchers at Stanford in collaboration with researchers at NYU have identified novel epitopes on Lymphocyte activation gene-3 (LAG-3) that regulate T cell activation. Blocking those LAG-3 epitopes has potential as a novel immune checkpoint inhibitor therapy.
Stanford scientists have developed a parametrically programmable delay line that uses superconducting circuits to store and manipulate quantum information with dynamic control capabilities.
Researchers in Professor Justin Sonnenburg's laboratory have developed genetic tools for manipulating Bacteroides, a prominent genus of gut bacteria, for imaging, diagnostics, and therapeutic drug delivery.
Stanford researchers have developed a novel mutant IL-9 receptor (IL9R) that significantly enhances the in vivo engraftment, expansion, and anti-tumor activity of adoptively transferred T cells.
Stanford researchers have developed MONTAGE, a powerful computational framework designed to identify groups of cells, called spatial communities, and map how these groups change across biological functions linked to cancer progression.