Researchers at Stanford University have found that recombinant osteopontin (SPP1) protein reduces foreign body response (FBR) and thereby facilitates successful integration and function of implantable devices.
Elastin-like polypeptides (ELPs) are promising biomaterials for medical applications due to their non-immunogenicity, scalable synthesis, and tunable self-assembly.
Researchers in Prof. Paul George's laboratory have patented a conductive polymer scaffold designed to electrically stimulate neural progenitor cells (NPCs) for enhanced neural regeneration.
Type 1 regulatory T cells (Tr1s) are an inducible subtype of regulatory T cells that can play a beneficial (autoimmune diseases, allergy, hematological malignancies) or detrimental role (some solid tumors and infectious diseases) in human diseases. Tr1 cells.
Stanford researchers have developed a new gene editing approach that enables red blood cell-specific gene expression for the treatment of enzyme deficiencies.
There is broad potential to modulate RNA using small molecules, replacing more costly and difficult-to-administer oligonucleotide therapies. However, methods for screening for such small molecules are lacking.
Stanford researchers have developed a scalable assay that combines single-molecule nucleic acid imaging with single-cell sequencing, enabling the enrichment and detailed study of rare cell populations in complex biological samples.
Patients with celiac disease have a pathological reaction to gluten and have either HLA-DQ2+ (90%) or HLA-DQ8+, but expression of these MHC class II haplotypes is not sufficient and other factors are necessary for the development of celiac sprue.
Different drug delivery agents, including synthetic polymers, virus-based vectors, lipid-based vectors, and extracellular vesicles (EVs), have been explored previously.
Stanford scientists have developed a working model that chemotherapy drugs induce peripheral neuropathy by activating a pathway that favors neuronal degeneration and impairs sensory neuron function.
Clinician-scientists at Stanford have proposed a WNT formulation that, when used in combination with a first-of-its-kind normothermic perfusion device, reconditions marginal organs and enables their safe transplantation.
Inventors at Stanford have developed a novel strategy to perform concurrent fluorescence measurements of multiple biological parameters in freely moving and head-restrained animals.