Researchers in Prof. Karl Deisseroth's laboratory have developed a system to enhance optogenetic pumps using one tool to address current limitations in both inhibition and excitation.
Researchers in Prof. Robert Malenka's laboratory have developed a light-activated animal system that could be used to identify compounds that treat certain psychiatric disorders.
Researchers in Prof. Emmanuel Mignot's laboratory developed a mouse monoclonal antibody to the N-terminal end of the hypocretin-1 protein (Hcrt-1, also known as orexin-A).
Electroosmotic (EO) pumps (also known as electrokinetic pumps) generate fluid flow and pressure in a compact system with no moving parts. They can be combined with microchannel heat exchangers to provide cooling for microelectronics. Researchers in Dr.
Stanford and Rockefeller researchers have identified and developed dynein-specific inhibitors that have significant medical applications involving mitotic spindle assembly, organelle transport, and primary cilia formation.
Researchers in Dr. Or Gozani's laboratory have produced lysine methyltransferases, histone octomers, purified nucleosomes, and antibodies for use in chromatin and epigenetic research.
Researchers in Dr. Michael Cleary's laboratory at Stanford University have developed a highly specific monoclonal antibody for AF5, a proto-oncoprotein associated with pediatric and adult acute leukemia.
Researchers in the laboratories of Dr. Eric Kool and Dr. Howard Chang have created and characterized chemical probes that enable accurate RNA structural analysis in living cells. RNA structure plays an important role in practically every facet of gene regulation.
Researchers in Dr. Laura Attardi's lab have created a knock-in mouse strain which generates a form of p53 that is not subject to degradation by the proteasome.
Researchers in Dr. Roeland Nusse's laboratory have generated an Axin2CreERT2 knock-in mouse strain that can be used to identify and map stem cells in any tissue. The Wnt/β-catenin signaling pathway is instrumental for stem cell maintenance in multiple tissues.
Engineers in the Stanford Microfluidics Laboratory have developed a sensitive, high-resolution, label-free detection method for identifying and quantifying analytes on chip-based electrophoretic assays.
Hemizygous mice are viable and fertile with no anatomic abnormalities. Transgene expression is observed in aorta, heart, and brain. Transgenicdimethylarginine dimethylaminohydrolase (DDAH) activity is reflected in a reduction of plasma asymmetric dimethylarginine (ADMA).