The Ji lab has developed a sequencing assay to provide genetic diversity information of microsatellite and chromosomal instability (MSI) in colorectal cancer. MSI arises from a loss of DNA mismatch repair in colorectal cancers, making them genetically diverse.
Radiation therapy is a common option in diseases like breast cancer, but can also cause significant damage to the skin. Permanent scarring and fibrosis can result, with both aesthetic and functional consequences for cancer patients.
Neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have been characterized by the expansion of the GGGGCC hexanucleotide repeat within the non-coding region of the human chromosome 9 open reading frame 72 (C9ORF72) gene.
Researchers at Stanford have developed, for the first time, a high-throughput method to systematically detect and identify silencer elements in the human genome.
These dual-function nanoparticles improve selectivity of myeloid treatment via identification and reduction of tumor progression in a two-step process: initial accumulation in tumor microenvironments, followed by targeted delivery of a therapeutic payload.
Stanford researchers have developed one of the smallest, active translational enhancers that can be adapted to control gene regulation. The translation enhancer is a short RNA stem-loop structure isolated from a Hox gene.
Stanford researchers have found a solution to enhance mRNA translation and stability by harnessing SARS-CoV2 genomic sequences themselves. They discovered that the SARS-CoV2 5' untranslated region (5' UTR) can be repurposed for increased translation and stability of any mRNA.
Stanford researchers have discovered that ribonucleoside vanadyl complexes can be used as an additive in transcription reactions resulting in ~2-fold increased yield.
A novel method for dissociating plant tissues for biochemical and genomic analysis that accommodates harsher digestion conditions with increased tissue dissociation efficiency and quality of isolated RNA.
Stanford researchers in the laboratory of Dr. Daria Mochly-Rosen have developed novel small molecules for modulating ALDH2 (mitochondrial aldehyde dehydrogenase-2).
Stanford researchers have formulated a risk scoring calculator using a human induced pluripotent stem cell (iPSC) model to accurately predict and calculate insulin resistance via a novel blood test.