Stanford researchers have developed an LVCTM3 system for producing lentiviral vectors and other viral particles, offering a cost-effective, simplified and scalable solution for various applications from gene therapy to vaccine development.
The lack of effective treatments for myocardial ischemia and reperfusion injury has been a major challenge in decreasing mortality rates from myocardial infarctions. Stromal cell-derived factor-1?
Early detection of ovarian cancer is crucial, with a 5-year survival rate exceeding 90%. Once this early window has been missed, the 5-year survival rate precipitously drops below 50%.
Researchers at Stanford University have formulated a novel biomaterial suitable for three-dimensional (3D) bioprinting: a homogeneous composite of polycaprolactone (PCL), gelatin, and beta-tricalcium phosphate.
Stanford inventors have devised a method of multiplexing droplet reactions to analyze and identify many reactions in parallel on a single microfluidic chip using off-the-shelf flow control and valving.
Researchers at Stanford have invented a novel hydrogel with enhanced retention and extended durability. This hydrogel can be held together three times longer than many alternatives without sacrificing its self-healing attributes during injection.
Adeno-associated virus (AAV) vectored products are currently leading candidates for gene therapy applications with multiple approved products and many more in clinical trials.
Stanford researchers have developed a new class of materials that enable new strategies for the efficient delivery of messenger RNA (mRNA) into cells and animals. The delivery materials are easily prepared (2 steps), stable and readily tuned.
Current injectable hydrogel materials have fast erosion and limited tunability of their mechanical properties at different stages of applications, limiting their biomedical applications.
Researchers at Stanford have developed a new therapeutic to promote survival of retinal ganglion cells (RGCs) and optic nerve regeneration after traumatic injury or optic neuropathies.
A team of researchers at Stanford and the University of Connecticut have developed a method to deliver contrast agents through a patient-friendly sublingual or buccal film that provides prolonged continuous release for ongoing optical imaging.
Researchers at Stanford have developed methods to overcome the limited packaging capacity of adeno-associated virus (AAV) vectors and enable their use in integration of large transgenes.
Stanford researchers have developed a method that can tune the ratio between reversible (RE) and irreversible (IRE) electroporation through waveform adjustments.
Stanford researchers at the Sattely Lab have discovered six podophyllotoxin biosynthetic genes and their polypeptide products from the plant, Podophyllum hexandrum (mayapple).
Researchers in Dr. Mark Kay's laboratory at Stanford University have designed a new liver-specific expression cassette for inserting genes into double-stranded AAV (adeno-associated virus) vectors for gene therapy.