To date, there are no treatments to restore neurologic function for the 7 million US patients suffering from chronic ischemic stroke. NR1 therapy provides a novel treatment for this unmet need.
Despite their rapidly expanding therapeutic potential, human pluripotent stem cell (hPSC)-derived cell therapies continue to have serious safety risks.
Researchers at Stanford have developed chemically defined, polyvinyl alcohol (PVA)-based media for culturing hematopoietic stem cells and immune cells (e.g., T cells).
Stanford researchers in the laboratory of Dr. Daria Mochly-Rosen have developed novel small molecules for modulating ALDH2 (mitochondrial aldehyde dehydrogenase-2).
Stanford researchers have proposed the use of a conductive graphene scaffold (CGS) as a biocompatible scaffold for growth of neural tissues. The high conductivity enables the use of electrical stimulation to control the development of induced pluripotent stem cells (iPSCs).
A team of Stanford scientists have developed a technique to rapidly convert adult somatic cells directly into functional neuronal cells without the intermediate step of generating iPS cells (induced pluripotent stem cells).
Stanford researchers have derived human multipotent germline stem cells (hMGSCs) from a testis biopsy. The biopsied cells show multiple characteristics of pluripotency.
Stanford inventors have developed a mesenchymal stem cell-based gene therapy that can target the inflammatory environment and secrete immunomodulatory cytokines. The model has been demonstrated in bone marrow mesenchymal stem cells in vitro.
Researchers at Stanford have engineered proteins to selectively sensitize T cells to IL-2. The ability to manipulate immune cells for therapeutic use is of great clinical interest. Cytokines are signaling molecules that can be used to alter cellular behavior.
Researchers in Prof. Irving Weissman's lab have developed and patented antibodies and methods to prevent the formation of teratomas from human pluripotent stem cells used for regenerative medicine, cell therapy or research.
Researchers at Stanford have developed methods to identify, isolate, and use specific progenitor cell populations to generate adipose tissue and functional blood vessels in vivo.