Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Mucins are known to be involved in tumor-progressive pathways but are difficult to target using small molecules and antibodies.
Stanford researchers have made a genetic mouse model to mimic the human LOXHD1 p.R1090Q mutation as a means to further investigate, understand and combat human Age-Related Hearing Loss (ARHL).
Stanford scientists have invented a new suite of adaptable hydrogel biomaterials that are optically transparent and injectable for cell encapsulation, tissue engineering, and drug delivery.
Stanford researchers have designed a new 3-dimensional (3D) hydrogel cell culture system that models native tissue environment with precise control over gelation and degradation properties.
Stanford scientists in Dr. Paul Wender's lab have developed a novel method to synthesize tigilanol tiglate (EBC-46) and related compounds from readily available starting materials.
Fast, accurate and cheap synthesis of ultralong strands of DNA is an essential foundation for synthetic DNA technologies such as cellular programming and engineering.
A team of Stanford engineers has identified first-in-class epidermal growth factor (EGF) mutants with enhanced activity. These mutants can stimulate increased EGF receptor activation at 10-fold lower concentrations than wild-type EGF.
Stanford researchers from the Khuri-Yakub group have designed an improved, high spatial resolution ultrasonic neuromodulation device that implements chip waveform instead of continuous wave PIRF.
Stanford researchers developed a new technology that prints networks with distinct branch structures that emulate the natural branching observed in in vivo vascular networks.
Metagenomic sequencing offers a powerful approach for the comprehensive monitoring and detection of pathogenic bacteria in food, clinical samples, and the environment.
Stanford researchers have developed a device that combines one-photon and two-photon microscopy using fast temporal multiplexing enabling 3D alignment between in vivo and ex vivo data for neuroscience and spatial biology applications.