Researchers at Stanford have developed methods to overcome the limited packaging capacity of adeno-associated virus (AAV) vectors and enable their use in integration of large transgenes.
MRG mdx4Cv: These mdx4Cv/NRG mutant mice are an immune-deficient irradiation resistant model of Duchenne muscular dystrophy (DMD) for transplantation experiments with human cells, such as human induced pluripotent stem cells (hiPSC).
Transgenic mice carrying reporter genes are extremely useful tools in modern biomedical science to unravel various underlying molecular mechanisms crucial for normal development, as well as, disease progression.
Researchers at the Solgaard Lab have demonstrated that light sheet fluorescence microscopy (LSFM) with structured and pivoting illumination enables fast image acquisition and improved image quality.
Stanford researchers have developed a quantitative, noninvasive, and early predictor of viability at the early embryo and oocyte stage using mechanical biomarkers.
Researchers in Prof. Julia Salzman's laboratory have developed a sensitive, specific algorithm for automated, high-throughput detection of RNA fusions from RNA-Seq data.
Stanford researchers have patented protein stability regulation methods using destabilizing domains (DDs) optimized for use in humans. The ability to control specific protein abundance in cells is a powerful tool for gene therapy and investigating biological behavior.
Professor Marc Levoy and collaborators have enhanced the performance of the light field microscope (LFM) by solving the problem of non-uniform spatial resolution across the working range, especially the low spatial resolution at the native objective plane (in the middle of the
The technologies described in this patent address a critically important deficit in the statistical methods available to enable comparison of outcomes measured by flow cytometry or similar, data intensive technologies.
Researchers in Prof. Karl Deisseroth's laboratory have developed an optical imaging and optogenetics two photon laser system that uses a single beam to illuminate many sites in three-dimensions.
Researchers at Stanford have created a monoclonal antibody to CD6. CD6 is a surface molecule expressed on T cells and some B cells. It may also play a role in diseases such as multiple sclerosis and rheumatoid arthritis.
Enzymatically active hydrogenase is synthesized in a cell-free reaction. The hydrogenases are synthesized in a cell-free reaction comprising a cell extract derived from microbial strains expressing at least one hydrogenase accessory protein.
Mice hemizygous for the MRP8-Cre-ires/GFP transgene are viable and fertile, with the human S100 calcium binding protein A8 (calgranulin A) (MRP8 or S100A8) promoter directing bicistronic Cre and EGFP protein expression to granulocytes and granulocyte/macrophage progenitors (GM
Researchers in Dr. Hanlee Ji's lab have developed a targeted sequencing method known as short tandem repeat (STR) sequencing (STR-Seq) which improves target selection specificity to generate only the STR spanning reads.
Stanford Prof. Juan Santiago and a team of engineers have developed a method of speeding up chemical reactions between a probe on a surface and a molecule in solution.