Despite their rapidly expanding therapeutic potential, human pluripotent stem cell (hPSC)-derived cell therapies continue to have serious safety risks.
Collagen-based hydrogels behave similarly to the native tissue microenvironment, thus are widely used as scaffolds for encapsulating cells or molecules like growth factors. Collagen solution is an injectable liquid until it crosslinks at 37 C and physiological pH.
Researchers at Stanford have developed a microparticle-based vaccine that in a single shot enables enhanced activation of CD8+ and/or CD4+ T cells to fight against infectious diseases and cancer.
Engineered cytotoxic T cells are a promising class of cell therapies. These living drugs are capable of selectively killing blood cancers, such as acute myeloid leukemia (AML), and delaying its progression.
Researchers at Stanford have developed chemically defined, polyvinyl alcohol (PVA)-based media for culturing hematopoietic stem cells and immune cells (e.g., T cells).
Researchers at Stanford have developed a new catalog of compact transcription effector domains and fused them onto DNA binding domains to engineer synthetic transcription factors.
Stanford researchers have identified a biomarker on cartilage precursor cells that can predict which cells will develop into inflammation-resistant and functionally appropriate tissue for autologous transplants to treat osteoarthritis.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an efficacious therapy for patients with life-threatening leukemias, but its use has been hindered by the limited availability of donors with matching HLA. Graft manipulation by removing ??
Researchers at Stanford have developed an oxygen-generating, collagen-based cryogel bioscaffold to improve islet cell transplantation for the treatment of diabetes. Type 1 diabetes, which affects millions of people, is currently treated by daily injection of insulin.
Researchers at Stanford have developed agents to enhance the therapeutic efficacy of a variety of anti-cancer therapeutics. Cell loss by apoptosis occurs in normal development and in tumor environments.
Stanford researchers have proposed the use of a conductive graphene scaffold (CGS) as a biocompatible scaffold for growth of neural tissues. The high conductivity enables the use of electrical stimulation to control the development of induced pluripotent stem cells (iPSCs).
A team of Stanford scientists have developed a technique to rapidly convert adult somatic cells directly into functional neuronal cells without the intermediate step of generating iPS cells (induced pluripotent stem cells).