Stanford researchers have developed a framework describing an end-to-end approach that infers experimental properties directly from nucleic acid sequence, using a principled statistical mechanical representation of the structure ensemble.
Stanford researchers have developed a multi-omics method for predicting the strength and durability of immune responses to vaccines shortly after vaccination. The COVID-19 pandemic was a grave demonstration of the threat pandemics pose to global public health.
Researchers at Stanford University have developed a method to induce antigen-specific immunological tolerance to allow for more effective gene replacement therapy for Duchenne muscular dystrophy (DMD).
The emergence of SARS-CoV-2 variants during the COVID-19 pandemic has demonstrated a need for broad immunization, such as provided by multivalent vaccines.
mRNA_hotfix is heuristic approach to adapt a stabilized mRNA to code for a protein mutation variant substitutes mutated codons with codons that maintain low predicted degradation.
Researchers at Stanford have developed a microparticle-based vaccine that in a single shot enables enhanced activation of CD8+ and/or CD4+ T cells to fight against infectious diseases and cancer.
Researchers at Stanford and the Chan Zuckerberg Biohub have discovered cross reactive, broadly neutralizing human antibodies against all serotypes of dengue virus.
Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed PMD (Protect, Modify, Deprotect), an immunofocusing strategy that can be used in vaccine development for the generation of antibodies targeting a specific epitope.
Stanford researchers have developed one of the smallest, active translational enhancers that can be adapted to control gene regulation. The translation enhancer is a short RNA stem-loop structure isolated from a Hox gene.
Stanford researchers have found a solution to enhance mRNA translation and stability by harnessing SARS-CoV2 genomic sequences themselves. They discovered that the SARS-CoV2 5' untranslated region (5' UTR) can be repurposed for increased translation and stability of any mRNA.