A common hurdle for many drug delivery applications is getting the desired compounds to the targeted cells or receptors. Additional barriers of achieving the therapeutic drug concentration and necessary drug diffusion are also present even after successful targeted delivery.
Stanford researchers have developed high-titer bacteriophage and annexin V formulations for rapid, more effective phage therapy against bacterial infection.
Proliferative vitreoretinopathy (PVR) is a rare ocular condition that can lead to vision loss or blindness and is a complication of rhegmatogenous retinal detachment, severe diabetic retinopathy, and other conditions.
Low doses of agents that activate BMP signaling (such as FK506) could be used to prevent the progression of bladder cancer and potentially treat breast, colon and other types of epithelial-derived cancer. This technology is based on the discovery by Prof.
Recent studies have linked microglia damage to various neurodegenerative and aging brain diseases. Relatedly, bone marrow transplantation has been shown to result in incorporation of macrophages into the brain, but the incorporation is variable, slow and inefficient.
Researchers at Stanford University have identified molecular regulators that can act as part of a personalized treatment plan to help treat hormone-related conditions, including pregnancy and infertility.
Stanford researchers at the Thakor Lab have developed methods for kidney tissue regeneration using pulsed focused ultrasound (pFUS) therapy with mesenchymal stromal cells (MSCs) and/or MSC-derived extracellular vesicles (e.g., exosomes or microvesicles).
Radiation is often an effective treatment modality for cancer, but its effects are limited to the targets that are directly irradiated. Regions of tumor outside the radiation field do not experience direct radiation-induced DNA damage and cellular apoptosis.
Jennifer Cochran and Carolyn Bertozzi have collaborated to develop a bifunctional molecule called a polyspecific integrin-binding peptide (PIP)-LYTAC that can bind to integrins expressed on the surface of cancer cells and trigger their degradation via the lysosome.
Stanford researchers have applied large-scale proteomic platforms to identify biomarkers that can be used to diagnose uveal melanoma and subtype eye tumors according to their gene expression profile (GEP) class or PRAME status.
Psoriasis is a chronic skin inflammatory disease that affects 7.5 million people in the US and accounts for $1.2 billion in annual direct medical costs.
A team of researchers at Stanford have developed a hydrogel that delivers a scar-reducing focal adhesion kinase inhibitor (FAK-I) to skin grafts and donor sites.