Overweight and obesity are linked to an increased risk and worsened outcome from many cancers, including colorectal, pancreatic and breast cancer, but the mechanisms responsible for these phenomena are unknown.
Stanford researchers have developed a novel methodology for the high-throughput expression and kinetic characterization of numerous enzyme variants in parallel using microfluidic droplet arrays.
Scientists in the Carette Lab at Stanford have developed AAV-Titer cell lines that enable (1) improved and standardized in vitro potency assays (2) determination of a functional titer of AAV vectors of different serotypes and containing different promotors.
Stanford researchers have defined subgroups of regulatory T cell (Tregs), CD39+ and CD39-, that can be genetically engineered to produce enhanced or reduced cytotoxicity without affecting their ability to suppress the immune system.
The recognition of peptide-MHC (pMHC) complexes by T cells is the cornerstone of cellular immunity, enabling the elimination of infected or tumoral cells. pMHC can thus be leveraged as a detection tool for T cells.
Researchers at Stanford University have discovered a first-in-class covalent inhibitor that binds to activated Fis1 and prevents mitochondrial fission and dysfunction.
Researchers at Stanford have developed a computational tool that enables the discovery of regenerative cells across all tissue types and novel targets in cancer.
Stanford researchers have developed tissue-based profiling by deep sequencing for detection of Minimal Residual Disease (MRD) by tracking patient-specific tumor mutations in post-chemotherapy tissue samples, enabling a highly sensitive, molecular-level assessment of residual c
Researchers at Stanford have developed fusion proteins, containing ACE2 domain linked to a fragment of non-neutralizing anti-SARS-CoV-2 spike protein antibody, with a greater breadth of protection than previously described similar fusion proteins.
Researchers at Stanford have developed fully genetically-encodable lysosome-targeting chimeras which allow for the targeted delivery of various proteins into receiver cells.
Stanford researchers at the Kasevich Lab have developed a module that can attach to any standard optical system or sensor for wide-field, time-resolved imaging.