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Wnt genes provide important signals dugin development and tumorigenesis, but their mechanism of action is poorly understood. We have developed a novel cell culture assay for the Drosophila Wnt gene wingless, using a Drosophila imaginal disc cell line.

A method of using neuregulin antagonists to delay the time of tumor recurrence in cancer patients has been developed by Dr. Sweet-Cordero and collaborators. This technology is available for non-exclusive license.

Researchers at Stanford have developed a clinically applicable method of bone marrow conditioning for stem cell transplantation or treatment of hematologic malignancies.

This invention consists of mouse L1/2 pre B cells and human Jurkat cells transfected with serpentine receptors. These cell lines have been shown to be induced by specific ligands to activate lymphoid cell integrins and hence cell adhesion.

Researchers at Stanford University have discovered a novel way of treating dry age-related macular degeneration by inhibiting a causal disease target.

The Rai1-Tag knock-in allele expresses a FLAG/myc-tagged RAI1 (Rai1-Tag) before Cre recombinase exposure. Cre-mediated deletion of the floxed FLAG-myc-STOP sequence results in expression of RAI1/EGFP fusion protein (Rai1EGFP).

Stanford researchers in the Snyder lab have discovered and developed an innovative immunoglobulin modality for the treatment of insulin resistance and type 2 diabetes.

Uveitis is an intraocular inflammation in the eye and represents a major cause of visual impairment and blindness worldwide.

Stanford scientists have discovered a previously unrecognized blood immune cell marker for osteoarthritis (OA) early detection.

Stanford researchers have developed REULR (Receptor Elimination by E3 Ubiquitin Ligase Recruitment), a mix and match nanobody (VHH)-based extracellular targeted protein degradation (eTPD) platform.

Rab proteins represent a large family of ras-like GTPases that regulate distinct vesicular transport events at the level of membrane targeting and/or fusion.

Mammography is the current first-line imaging technique for early breast cancer detection, however, its diagnostic accuracy is limited in women with dense breast tissue. Ultrasound is often performed as a second line test in women with dense breast tissue.

Stanford researchers have invented a novel nanobody-based platform for specific activation of bone and cartilage regeneration.

Stanford researchers have identified exercise-inducible, carboxylesterase 2 (CES2) proteins, which suppress obesity in high fat diet-fed mouse models. Generally, CES2 proteins are intracellular and localized to the endoplasmic reticulum.